Featured Studies

Crohn's disease is a chronic bowel illness that is a lifelong condition characterized by relapsing inflammation. Although there is no cure for Crohn's disease, researchers at the National Institutes of Health (NIH) are investigating if Vorinostat is safe for people with Crohn's Disease. Participants will receive maintenance therapy with Stelara® after successful treatment with Vorinostat.

The National Institutes of Health (NIH) is seeking children and adults with osteogenesis imperfect (OI) to join a study to learn more about the natural history of OI from childhood to adulthood and identify genes that play a role in the disease. This study is a part of the NIH Osteogenesis Imperfecta Translational Research Program, led by physician scientist, Joan Marini, M.D., Ph.D. The program has provided comprehensive care for children with OI for more than 30 years, while conducting clinical and laboratory research.

Researchers at the National Institutes of Health (NIH) are studying if the medication danazol can be used to treat people with short telomere disease who also have bone marrow failure, liver, or lung disease. In recent studies, danazol, at high doses, showed a positive influence on telomere length. Additional research is needed to learn more about the role of different doses of danazol on telomere disease as well as its effects on secondary diseases.

National Institutes of Health (NIH) researchers are enrolling patients with kidney cancer (renal cell carcinoma) into a gene therapy study - a new type of precision medicine that genetically reprograms your immune cells to specifically recognize and kill tumor cells. With this new gene therapy, we genetically reprogram your own T-cells to recognize a specific part of the HERV-E protein expressed on your kidney cancer cells that now enables these T-cells to kill your tumor cells. This is an early phase trial in partnership with Loyola University Chicago looking at whether this gene therapy is safe and benefits patients.

National Cancer Institute (NCI) researchers are conducting a study of patients with IDH-mutated gliomas. This study will test whether stimulating the immune system using the drug nivolumab can shrink recurrent IDH-mutant gliomas with and without hypermutator phenotype or increase the time it takes for them to grow or spread.

Researchers at the National Institutes of Health (NIH) are investigating if nivolumab given in combination with tadalafil and vancomycin may help liver tumors to shrink. This research study may provide answers for a new treatment that may help patients with hepatocellular carcinoma or metastases to the liver from colorectal or pancreatic cancer for which standard treatment has not been of benefit.

Hepatocellular Carcinoma (HCC) is the fifth most common cancer in the world. Patients with advanced HCC survive an average of 6 to 9 months. Researchers at the National Institutes of Health are testing the use of an immunotherapy medication called durvalumab, with two other chemotherapy medications, doxorubicin-eluting beads and bevacizumab. This clinical research study will investigate if this combination of medications can stop the progression of HCC.

Doctors at the National Institutes of Health (NIH) seek patients with thyroid cancer that spread outside the thyroid - to the lymph nodes, lungs or bones. The standard treatment in such situation is therapy with radioactive iodine (RAI). In this study, doctors will assess a new imaging tool - 124I PET/CT, which enables evaluation of how much iodine goes into the tumor. The study goal is to compare how much iodine goes into cancer cells after two different methods of stimulation of RAI uptake.

The research study sets out to learn about changes in the genetic makeup of CLL during the early phase of treatment with venetoclax. The initial phase of venetoclax therapy can be medically and logistically challenging. Patients will receive expert medical care at the National Institutes of Health (NIH).

Doctors at the National Institutes of Health (NIH) are conducting a study on patients with clonal hematopoiesis of indeterminate potential (CHIP). Patients with CHIP have a genetic mutation that has been associated with blood cancer. The study will look at CHIP and try to determine its relationship to blood cancers and heart disease. The study will also try to discover other new organs or diseases that may be linked with.