A Phase 1 Study to Evaluate the Safety and Tolerability of Escalating Doses of VAS-101 in Subjects with Stable Sickle Cell Disease
NIH researchers are seeking adults aged 18 and older with sickle cell disease for a research study evaluating VAS-101 gel, an investigational product containing curcumin, to determine whether it is safe and well-tolerated.
Advancing Treatment Options for Recurrent Glioblastoma
Adults with recurrent glioblastoma may be eligible for an NIH research study evaluating LMP744, an investigational drug with FDA orphan drug designation for gliomas. The study aims to assess the drug's safety and both its short- and long-term treatment effects.
Prospective Cross-Over Study of the Effects of Meal Macronutrients on Postprandial Lipids
NIH researchers need volunteers with a health condition that affects how their body handles fats. Adults 18+ with conditions that affect how the body handles fats, like obesity, lipodystrophy, nephrotic syndrome, type 2 diabetes, and fatty liver, may be eligible to participate in a research study looking at how different fats in meals affect fat levels in the blood.
Prospective Cross-Over Study of the Effects of Meal Macronutrients on Postprandial Lipids
Healthy Volunteers Needed for Nutrition & Heart Health Research. Researchers at the National Institutes of Health are studying how meals with different nutrient levels affect fats in the blood, which may play a role in heart disease and other health conditions.
Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjögren's Disease Phase IIa Open-Label Clinical Trial and Associated Mechanistic Studies
Dr. Blake Warner and a group of NIH researchers are testing tofacitinib, an investigational oral medication, to help better understand and treat Sjögren's symptoms. Tofacitinib is already approved by the United States Food and Drug Administration (FDA) for other autoimmune conditions and is being used investigationally in this research study.
Observational Study of Dietary Intake and Dietary Behaviors in Adults with Sickle Cell Disease
Are you living with sickle cell disease (SCD)? You may wonder how diet and nutrition affect your overall health and well-being. Researchers at the National Institutes of Health (NIH) are conducting a study to investigate how diet and nutrition impact the physical and mental health of adults with SCD.
VRC 329: A Phase I Open-Label, Clinical Trial To Evaluate the Safety, Tolerability, and Immunogenicity of a Quadrivalent Influenza HA Stem Vaccine VRC-FLUMOS0122-00-VP (STEMos1) With and Without ALFQ Adjuvant in Healthy Adults
Researchers at the NIH Clinical Center are conducting a research study for an investigational vaccine that targets influenza (flu).
THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins
Dr. Komarow and his team at the National Institutes of Health (NIH) are conducting a clinical research study to better understand how everyday environmental exposures may affect allergic and inflammatory responses in healthy adults. With allergic and inflammatory conditions increasing over time, this study aims to explore how common substances in air, food, and personal care products influence human health.
Oral Microbial and Immunological Characterization of Patients with Immune Dysfunction
Gum disease (periodontal disease) is being studied at the NIH Clinical Center. Researchers want to learn how a person's immune system affects the health of the mouth. If you have gum disease and want to learn how you can participate contact us.
Is Your Child Struggling To Sleep Through the Night? It Could Be Sleep Apnea, and NIH Researchers Are Working on New Ways To Help
The NIH Clinical Center is studying an investigational wearable device, not approved by the FDA, that children wear during sleep to measure oxygen levels and collect important information about their health. Your child's participation could help advance pediatric sleep research while receiving a no-cost research evaluation. Compensation provided.