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Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting with Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus

Don't Let Lupus Stop You!

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Women with Systemic Lupus Erythematosus (SLE) are more likely to have dysregulation of the innate immune system. Due to this observation, a team from the National Heart, Lung, and Blood Institute (NHLBI) is investigating if a dietary supplement called nicotinamide riboside (NR) decreases some markers of inflammation in the blood and will research the connection between immune cell activity and immune cell energy metabolism in healthy women volunteers and volunteers with lupus.

Study Design:

  • Participants will have a review of medical history, physical exam, and lab testing
  • People with SLE will be asked to take the supplement or placebo for 12 weeks
  • Healthy volunteers will not receive study capsules

Who can participate:

  • Females 18+ years old with SLE, or female healthy volunteers without a history of autoimmune or inflammatory disease
  • Not pregnant or breastfeeding

The NIH Clinical Center, America's Research Hospital, is located in Bethesda, MD, on the Metro Red Line (Medical Center stop).

For more information:
NIH Clinical Center Office of Patient Recruitment
800-411-1222
TTY users dial 7-1-1
Email: ccopr@nih.gov

Or go online:
https://go.nih.gov/GyIFtVv
Refer to study # 001621-H

Follow us on Instagram @nih_ccopr

Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Heart, Lung and Blood Institute (NHLBI)