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Featured Studies

This web page makes it easy to search for featured research studies at the NIH Clinical Center. You can search for specific studies by entering keywords related to your symptoms in the search box or by using the sort and filter options.


To view a full list of all studies conducted at the NIH Clinical Center, visit Search the Studies.

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132 results
The Pathological Basis of MRI Signal Changes in Multiple Sclerosis: A Longitudinal In Vivo-to-Postmortem Stud

The Pathological Basis of MRI Signal Changes in Multiple Sclerosis: A Longitudinal In Vivo-to-Postmortem Stud

Multiple sclerosis (MS) is a disease that damages the central nervous system (brain and spinal cord). This leads to increased physical disability over time. The disease is lifelong once it begins. Researchers want to learn more about the stages of multiple sclerosis and follow them until a person's death to understand how the physical and clinical signs of MS relate to its changes over time.
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Brain Dopaminergic Signaling in Opioid use Disorders (OUD)

Brain Dopaminergic Signaling in Opioid use Disorders (OUD)

The National Institutes of Health (NIH) is looking for volunteers who use opiates regularly or who are receiving treatment for opiate use. The purpose is to learn how opiates affect brain function.
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Brain Dopaminergic Signaling in Opioid Use Disorders

Brain Dopaminergic Signaling in Opioid Use Disorders

Researchers at the National Institutes of Health (NIH) Clinical Center seek healthy volunteers for a research study on opioid use disorder (OUD). The purpose of this research study is to learn how opiate use disorder affects dopamine signaling in the brain of people dependent on opioids.
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Nicotinic Receptor Genetic Variation and Alcohol Reward

Nicotinic Receptor Genetic Variation and Alcohol Reward

Researchers at the National Institutes of Health seek volunteers, 21-60 years old, to participate in a study researching if a gene and smoking affect drinking. All study-related tests and procedures are provided at no cost to the study participant. Compensation may be provided.
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Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients with Recurrent Select Rare CNS Cancers

Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients with Recurrent Select Rare CNS Cancers

National Cancer Institute (NCI) researchers are conducting a study of patients with rare central nervous system (CNS) tumors. More than 130 primary rare CNS (brain or spine) tumors have been identified. Most affect less than 2,000 people in the United States each year. This study will test whether stimulating the immune system using the drug nivolumab can shrink select rare brain or spine tumors or increase the time it takes for them to grow or spread.

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The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment with Beta-3-Adrenergic Receptor Agonists

The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment with Beta-3-Adrenergic Receptor Agonists

Women diagnosed with polycystic ovary syndrome (PCOS) needed for a research study at the National Institutes of Health (NIH). Researchers want to learn more about how a medication may be used to help your body's insulin work better and if this can improve your overall metabolic health.
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A Randomized Trial of Sirolimus (Rapamune(R)) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

A Randomized Trial of Sirolimus (Rapamune(R)) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

Severe aplastic anemia is a rare and serious blood disorder. Patients with severe aplastic anemia commonly receive Cyclosporine to help improve blood counts. When cyclosporine treatment stops, the disease may return in one in three people. Researchers at the National Institutes of Health (NIH) Clinical Center are studying if sirolimus, an immunosuppressant, can help prevent a relapse in patients diagnosed with severe aplastic anemia following cyclosporine treatment.
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