Research Scientist,
National Institutes of Health
Bethesda, MD
USA
Work Phone: (301) 594-3328
E-mail: samar.sayedyahossein@nih.gov
Education
PhD, Dept. of Physiology & Pharmacology, Western University, Canada
September 2010 - February 2015
Thesis: The role of Integrin-linked Kinase in the epidermis barrier function
Advisor: Dr. Lina Dagnino
MSc, (continued to PhD program), Dept. of Immunology, Western University, Canada
September 2008 - April 2010
Project: The immunomodulatory effect of Staphylococcus aureus Peptidoglycan-embedded molecules
Advisor: Dr. Joaquim Madrenas
MD, Isfahan University of Medical Sciences, Iran
September 1999 - February 2007
Thesis: Safety and efficacy of a novel glyceryl trinitrate suppository formulation in the treatment of chronic anal fissure
Advisor: Dr. Mohammad Hassan Emami
Professional Experiences
National Institutes of Health, Dept. of Laboratory Medicine, Bethesda, MD
Research Scientist
Laboratory of Dr. David B. Sacks
January 2023 - present
Western University, Dept. of Physiology & Pharmacology, London, ON, Canada
Research Scientist
Laboratory of Dr. Lina Dagnino
January 2020 - December 2022
Fanshawe College, School of Applied Science and Technology, London, ON, Canada
Part time faculty
January 2022 - present
Western University, Dept. of Anatomy & Cell Biology, London, ON, Canada
Postdoctoral Associate
Laboratory of Dr. Silvia Penuela
April 2018 - December 2020
Isfahan University of Medical Sciences, Dept. Genetics & Biology, Isfahan, Iran
Assistant Professor
July 2017 - March 2018
National Institutes of Health, Dept. of Laboratory Medicine, Bethesda, MD, USA
Postdoctoral Fellow
Laboratory of Dr. David B. Sacks
October 2015 - May 2017
Isfahan University of Medical Sciences, Isfahan, Iran
Family Physician
September 2007 - September 2008
Hakimane Shargh Company, Isfahan, Iran
Research Scientist (Biotechnology)
January 2004 - September 2008
Publications
Papers in refereed journals (from a total of 21 published; h-index= 12, 533 total citations, IF; impact factor)
Google Scholar
O'Donnell BL, Sanchez-Pupo RE, Sayedyahossein S, Karimi M, Bahmani M, Zhang CH, Johnston D, Kelly JJ, Wakefield BC, Barr K, Dagnino L, Penuela S. PANX3 Channels Regulate Architecture, Adhesion, Barrier Function, and Inflammation in the Skin. J Invest Dermatol, 2023 Feb 21;S0022-202X(23)00103-3. doi:10.1016/j.jid.2023.01.030 (IF=7.59).
S. Sayedyahossein, Z. Li, E. Barnaeva, J. Smith, J. Marugan, M. Ronzett, X. Hu, N. Southall, M. Ferrer, DB. Sacks. Potent small molecule inhibitors that disrupt IQGAP1-Cdc42 interactions. Scientific Reports, July 2022. Oct 17;12(1):17372. doi: 10.1038/s41598-022-21342-w (IF=4.99)
L. Thines, L. Gorisse, Z. Li, S. Sayedyahossein, D. B. Sacks. Calmodulin activates the Hippo signaling pathway by promoting LATS1 kinase-mediated inhibitory phosphorylation of the transcriptional coactivator YAP. J Biol Chem, 2022 March 17;101839 doi: 10.1016/j.jbc.2022.101839 (IF=4.27)
Wakefield CB, Lee VR, Johnston D, Boroumand P, Pillon NJ, Sayedyahossein S, O'Donnell BL, Tang J, Sanchez-Pupo RE, Barr KJ, Gros R, Flynn L, Borradaile NM, Klip A, Beier F, Penuela. Pannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner. Int J Obes (Lond). 2021 Dec 13. doi: 10.1038/s41366-021-01037-4 (IF=4.27)
S. Sayedyahossein, K. Huang, Z. Li, C. Zhang, AM. Kozlov, D. Johnston, D. Nouri Nejad, DH. Betts, DB. Sacks and S. Penuela. A direct Pannexin 1 interaction with -catenin mediates melanoma cell growth and metabolism. J Biol Chem, 2021 Feb 26;100478. doi: 10.1016/j.jbc.2021.100478 (IF=4.27)
D. Nouri Nejad, B. L. O'Donnell, C. Patil, RE. Sanchez-Pupo, D. Johnston, S. Sayedyahossein, K. Jurcic, Rebecca Lau, Laszlo Gyenis, DW. Litchfield, MF. Jackson, GB. Gloor, and S. Penuela. Pannexin 1 mutation found in melanoma tumour reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein, Mol Biol Cell, Jan 6th, 2021 (IF=3.9)
A. Varela-Vázquez, A. Guitián-Caamaño, P. Carpintero-Fernandez, E. Fonseca, S. Sayedyahossein, T. Aasen, S. Penuela and MD. Mayán. Emerging functions and clinical prospects of connexins and pannexins in melanoma. Biochim Biophys Acta (BBA) Rev Cancer 2020 May 24;1874(1):188380. doi: 10.1016/j.bbcan.2020.188380 (IF=6.8)
S. Sayedyahossein, A C. Hedman, D B. Sacks. Insulin suppresses the transcriptional activity of yes-associated protein (YAP). Mol Biol Cell 2020 Jan 15;31(2):131-141. doi: 10.1091/mbc.E19-04-0205 (IF=4.27)
TJ Freeman, S. Sayedyahossein, D. Johnston, RE. Sanchez-Pupo , B. O'Donnell , K. Huang , Z. Lakhani , D. Nouri-Nejad , KJ. Barr , L. Harland , S. Latosinsky , A. Grant , L. Dagnino , S. Penuela . Inhibition of Pannexin 1 reduces the tumorigenic properties of human melanoma cells. Cancers (Basel). 2019 Jan 16;11(1). pii: E102. doi: 10.3390/cancers11010102 (IF=6.16)
VR. Lee, KJ. Barr, JJ. Kelly, D. Johnston, CFC. Brown, KP. Robb, S. Sayedyahossein, K. Huang, R. Gros, LE. Flynn, S. Penuela. Pannexin 1 regulates adipose stromal cell differentiation and fat accumulation. Sci Rep 2018 Nov 1;8(1):16166. doi: 10.1038/s41598-018-34234-9 (IF=4.12)
B. Chawla, A C. Hedman, H H. Erdemir, S. Sayedyahossein, Z. Li, D B. Sacks. Absence of IQGAP1 leads to insulin resistance. J Biol Chem 2017 Feb 24;292(8):3273-3289 doi: 10.1074/jbc.M116.752642. (IF=4.27)
S. Choi, A C. Hedman, S. Sayedyahossein, N. Thapa, D B. Sacks and R A. Anderson. Agonist-stimulated PI 3,4,5 P3 generation by scaffolded phosphoinositide kinases. Nat Cell Biol, 18, pages1324–1335 (2016). doi:10.1038/ncb3441 (IF=17.72) *Highlighted in News and Views commentary by Nature Cell Biology editors: 2016 Nov 29;18(12):1263-1265. doi: 10.1038/ncb3440.
S. Sayedyahossein, Z. Li, A C. Hedman, C. Morgan and D B. Sacks. IQGAP1 modulates YAP transcriptional activity. J Biol Chem 2016 Sep 9;291(37):19261-73. doi: 10.1074/jbc.M116.732529 (IF=4.27)
S. Sayedyahossein, A. Rudkouskaya, V. Leclerc and L. Dagnino. Integrin-linked kinase is indispensable for keratinocyte differentiation and epidermal barrier function. J Invest Dermatol 2016 Feb;136(2):425-435. doi:10.1016/j.jid.2015.10.056 (IF=6.29)
S. Sayedyahossein, S. X. Xu, A. Rudkouskaya, M. J. McGavin, J. K. McCormick and L. Dagnino. Staphylococcus aureus keratinocyte invasion is mediated by Integrin-Linked-Kinase and Rac1. FASEB J 2015 Feb; 29(2):711-23 (IF=5.39)
L. Vi, S. Boo, S. Sayedyahossein, R. Singh, S. McLean; G. Di Guglielmo and L. Dagnino. Modulation of type II TGF-β receptor degradation by Integrin-linked kinase. J Invest Dermatol. 2015 Mar;135(3):885-94 (IF=6.29)
S. Sayedyahossein and L. Dagnino. Integrins and small GTPases as modulators of phagocytosis. Int Rev Cell Mol Biol 2013; 302:321-354 (IF=3.78)
S. Sayedyahossein, L. Nini, TS. Irvine, and L. Dagnino. Essential role of integrin-linked kinase in regulation of phagocytosis in keratinocytes. FASEB J 2012; 26(10): 4218-4229 (IF=5.39)
V. Frodermann, TA. Chau, S. Sayedyahossein, JM. Toth, DE. Heinrichs, J. Madrenas. A Modulatory Interleukin-10 response to Staphylococcal peptidoglycan prevents Th1/Th17 adaptive immunity to Staphylococcus aureus. J Infect Dis. 2011; 204(2): 253-262 (IF=5.0)
M.H. Emami, *S. Sayedyahossein. Chronic Anal Fissure: New approaches to chemical sphincterotomy. JRMS 2008; 13(3): 149-155 (IF=1.46)
*Corresponding author
M.H. Emami, *S. Sayedyahossein. A. Aslani. Safety and efficacy of new glyceryl trinitrate suppository formula: first placebo controlled clinical trial. Dis Colon Rectum 2008; 51 (7): 1079-1083 (IF=3.99)
*Corresponding author
Translations
Rodgers, Beth L. Developing Nursing Knowledge: Philosophical Traditions and Influences, trans. Ahmad Reza Yazdannik, Samar Sayedyahossein, Isfahan: Isfahan University of Medical Sciences, 2012. Print. ISBN: 978-964-524-436-9
Selected Awards, Honors, Fellowships, Scholarships
First Place Presentation Award
CCTS Summer Blitz Series 2022
Canadian Connective Tissue Society, 2022
The Coolen Postdoctoral Scholar Publication Award:
‘Best’ paper in 2020 Department of Anatomy and Cell Biology, Western University, 2021
Western Interdisciplinary Development Initiatives (IDI) in Stem cells and Regenerative Medicine Fellowship Award ($10,000)
Schulich School of Medicine, Western University, 2019
Margaret P. Moffat Award for Outstanding PhD Thesis
Department of Physiology and Pharmacology, Western University, 2015
Mogenson and Sharma Research Scholarship
Department of Physiology and Pharmacology, Western University 2014
Graduate Thesis Research Award
Department of Physiology and Pharmacology, Western University 2013
Western Graduate Research Scholarship (WGRS) ($10,500/Year)
Western Universityv * Competitively renewed for 6 years in a row 2008-14
UNESCO- L'OREAL Scholarship for Young Women in Life Sciences,
Nominee from Iran 2007
Pioneer Student Award,
Isfahan University of Medical Sciences, Isfahan, Iran 2007
Student Award of Excellence,
Isfahan University of Medical Sciences, Isfahan, Iran 2005
National Award of Leadership in Global Education,
Iranian Academic Center for Education, Culture and Research (Jahad Daneshgahi) 2004
Invited Talks
2021 - Future Leaders in Science, National Institutes of Health, Bethesda, MD, USA
Title: Role of scaffold proteins in signal transduction during tumorigenesis
2018 - Isfahan University of Medical Sciences, Isfahan, Iran
Title: The role of IQGAP1 in PI3K/AKT signaling.
2017 - Howard University Cancer Center, Washington DC, USA
Title: The scaffolding role of IQGAP1 in the Hippo pathway: implications in colon cancer.
Interviews
Featured Alumni, University of Western Ontario, Department of Physiology and Pharmacology, 2016
Student Profile: A spirited journey - Samar Sayedyahossein, 2014, Western Communications