Welcome to the website of the Sacks' laboratory! Our research focuses primarily on intracellular signal transduction regulated by scaffold proteins and Ca2+-sensing proteins. Current projects seek to identify new binding partners to those proteins, and to explore functional implications in cellular functions, physiology, and pathology. The research integrates an array of cell biology, biochemistry, and molecular biology techniques.
Our laboratory is part of the National Institutes of Health intramural research program. We are located in the Clinical Center on the NIH main campus in Bethesda, Maryland.
The research in the laboratory is directed towards elucidating the role of calmodulin and IQGAPs in signal transduction pathways.
Our major areas of interest include the disruption of the normal signaling pathways that result in cancer and microbial pathogenesis.
A diverse array of biochemical, cell biological, and molecular biological approaches are used in these investigations.
Research areas include:
Dr. David B. Sacks
Senior Investigator
National Institutes of Health
Email: sacksdb@mail.nih.gov
Phone: 301-496-3386
Read Curriculum Vitae