How Much Radioactive Iodine (RAI) Goes Into Thyroid Cancer Cells?
The standard treatment for metastatic thyroid cancer is radioactive iodine (RAI) therapy. For patients whose tumors do not take up RAI, re-differentiation therapy to re-induce RAI uptake is offered. During this clinical study, researchers will use a new imaging tool - 124I PET/CT to evaluate how much iodine gets into the cancer cells under to methods of preparation for RAI treatment: 1) An injection shot of a recombinant human thyroid stimulating hormone (TSH) 2) Stimulation with endogenous TSH, achieved by stopping thyroid hormone medication for four weeks.
The therapy with RAI will be individualized, tailored towards RAI kinetics in each patient individually to establish the precise optimal dose that does not harm the bone marrow, but accumulates sufficiently in cancer lesions.
Who Can Participate?
- 18 years or older
- Have thyroid cancer that has spread outside the thyroid
- Patients with established thyroid cancer who underwent total thyroidectomy with persistent/recurrent disease, either locally advanced or presenting with distant metastases; or
- Patients presenting with suspected persistent/recurrent or distant metastases based on high-risk features such as advanced tumor and/or elevated tumor marker thyroglobulin
In This Study, You Will:
- Have two inpatient admissions to the NIH Clinical Center, each for a week
- Return for 1-week follow-ups every year for the next 5 years
- Receive all study-related tests, procedures, and medications are provided at no cost. Travel and lodging may be provided.
The NIH Clinical Center, America's Research Hospital, is located in Bethesda, MD, on the Metro Red Line (Medical Center stop).
For More Information:
NIH Clinical Center Office of Patient Recruitment
800-411-111
TTY users dial 7-1-1
Email: ccopr@nih.gov
Or go online
Refer to NIH study # 19-DK-0050
Department of Health and Human Services
National Institutes of Health Clinical Center (CC)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)