Ping
Jin, MSc, PhD
Chief, Product Assurance and Characterization Testing Section
Center for Cellular Engineering
NIH Senior Associate Scientist
301-451-8501
Dr. Ping Jin is the Chief of the Product Assurance and Characterization Testing Section, Center for Cellular Engineering (CCE) and leads two clinical laboratories: the Flow Cytometry/Cell Counting Laboratory and the Molecular Assays Laboratory. These laboratories conduct in-process and lot-release testing of cell and gene therapies manufactured in the CCE and test patient cellular materials used in cell therapy manufacturing. In addition to clinical testing, Dr. Jin leads a research team which is focused on characterizing the mechanisms of action and critical biological qualities of cell and gene therapies developed in the CCE and used to treat NIH Clinical Center Patients.
MSc, Northeast Normal University, P.R. China
PhD, Northeast Normal University, P.R. China
Dr. Ping Jin received her Ph.D. in Genetics and Cytology from Northeast Normal University in P.R. China. She joined the NIH as a visiting fellow in 2003 and was promoted to Staff Scientist in 2005. She is currently the Chief of the Product Assurance and Characterization Testing Section in the Center for Cellular Engineering (CCE) and a Senior Associate Scientist at the NIH.
In addition to her role supporting investigators who use the core facility for patient care at PACT/CCE, Clinical Center, Dr. Jin has initiated, led, and collaborated on numerous translational research projects. These projects include the exploration of vector integration sites in CAR T-cell products, the cellular and genomic attributes of CAR T-cell products, and metabolic analysis of CAR cells.
Dr. Jin has extensive experience in assay development for cell and gene therapy. Through her leadership and proactive adoption of cutting-edge technologies, she has propelled PACT/CCE to the forefront of enhancing patient care and driving transformative advances in cellular and gene therapy research. Her contributions to translational research have resulted in over 90 publications, including significant studies on vector integration sites and the cellular and molecular characteristics of CAR T-cells.
Dr. Jin is a member of the Stability Testing Guidance Advisory Committee (STAC) at the NIH, which is a Subcommittee for the Sterile Produces for Human Use (SPHA) Committee, for the NIH Intramural Program and the member of the NIH Laboratory Managers Working Group (LMWG).
- NIH Clinical Center Special Honorific Award as a Senior Associate Scientist, 2024.
- Clinical Center 2024 CEO Award in recognition of moving the CCE Assays Laboratories and reorganizing its workflow without a disruption in service
- Clinical Center 2023 CEO Award for Mentoring. Bestowed for exemplary performance while demonstrating significant leadership, skill, and ability in serving as a mentor
- Clinical Center 2020 CEO award for Development of Novel Cell and Gene Therapies
- Clinical Center 2012 Director's Award for constantly providing outstanding mentoring and teaching to Visiting Fellows, pre IRTA students and research summer interns over the past seven years
Prochazkova M, Dreyzin A, Shao L, Garces P, Cai Y, Shi R, Pelayo A, Kim YS, Pham V, Frodigh SE, Fenton S, Karangwa C, Su Y, Martin K, Zhang N, Highfill SL, Somerville RP, Shah NN, Stroncek DF, Jin P. Deciphering the importance of culture pH on CD22 CAR T-cells characteristics. J Transl Med. 2024 Apr 24;22(1):384. doi: 10.1186/s12967-024-05197-5
Cai Y, Prochazkova M, Kim YS, Jiang C, Ma J, Moses L, Martin K, Pham V, Zhang N, Highfill SL, Somerville RP, Stroncek DF, Jin P. Assessment and comparison of viability assays for cellular products. Cytotherapy. 2024 Feb;26(2):201-209
Jinxia Ma, Lipei Shao, Tatyana Fuksenko, Hui Liu, Rongye Shi, Anh Dinh, Steven L Highfill, Nan Zhang, Sandhya R Panch, Robert P Somerville, David F Stroncek, Ping Jin. Reference gene selection for clinical chimeric antigen receptor T-cell product vector copy number assays. Cytotherapy. 2023 Mar 17;S1465-3249(23)00062-2. doi: 10.1016/j.jcyt.2023.02.010
Shao, Lipei; Shi, Rongye; Zhao, Yingdong; Liu, Hui; Lu, Alexander; Ma, Jinxia; Cai, Yihua; Fuksenko, Tatyana; Alejandra, Pelayo; Shah, Nirali; Kochenderfer, James; Norberg, Scott; Hinrichs, Christian; Highfill, Steven; Somerville, Robert; Panch, Sandhya; Jin, Ping*; Stroncek, David;; Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products, co- corresponding author, J Transl Med. 2022 Nov 8;20(1):514;* co-corresponding author.
Lipei Shao, Alejandra Pelayo, Rongye Shi, Jinxia Ma, Hui Liu, Yihua Cai, Robert P. Somerville, Sandhya R. Panch, Nirali N. Shah, David F. Stroncek and Ping Jin, Identification of genomic determinants contribute to cytokine release in immunotherapy and human diseases, J Transl Med. 2022 Jul 28;20(1):338
Lipei Shao, Avinash Iyer, Yingdong Zhao, Rob Somerville , Sandhya Panch, Alejandra Pelayo, David F Stroncek , Ping Jin, Identification of genomic signatures in bone marrow associated with clinical response of CD19 CAR T-cell therapy, Sci Rep, 2022 Feb 18;12(1):2830. doi: 10.1038/s41598-022-06830-3
Cai Y, Prochazkova M, Jiang C, Song HW, Jin J, Moses L, Gkitsas N, Somerville RP, Highfill SL, Panch S, Stroncek DF, Jin P. Establishment and validation of in-house cryopreserved CAR/TCR-T cell flow cytometry quality control. J Transl Med. 2021 Dec 24;19(1):523. doi: 10.1186/s12967-021-03193-7
Lu A, Liu H, Shi R, Cai Y, Ma J, Shao L, Rong V, Gkitsas N, Lei H, Highfill SL, Panch S, Stroncek DF, Ping Jin. Application of droplet digital PCR for the detection of vector copy number in clinical CAR/TCR T cell products. J Transl Med 2020 May 8;18(1):191. doi: 10.1186/s12967-020-02358-0
Liu S, Stroncek DF, Zhao Y, Chen V, Shi R, Chen J, Ren J, Liu H, Bae HJ, Highfill SL, Ping Jin. Single cell sequencing reveals gene expression signatures associated with bone marrow stromal cell subpopulations and time in culture. J Transl Med. 2019 Jan 11;17(1):23.