Michael B. Keller, MD, MS

MD, University of Miami School of Medicine
MS, Florida Atlantic University

Dr. Keller received his Bachelor of Science degree in Biology from Villanova University, his Master of Science degree in Biomedical Science from Florida Atlantic University, and Doctor of Medicine degree from the University of Miami. He completed residency training at Johns Hopkins Hospital in internal medicine, and then completed a fellowship in Critical Care Medicine at the NIH and fellowships in Pulmonary and Critical Care Medicine and Transplant Pulmonology at Johns Hopkins Hospital. He is actively board certified in Internal Medicine and Pulmonary and Critical Care Medicine.

His primary research interest is lung transplantation at the clinical and translational level. He is currently investigating the association of a novel molecular marker of lung allograft injury, percent donor-derived cell free DNA (%ddcfDNA), on a variety of clinical outcomes including primary graft dysfunction, acute rejection, infection and chronic lung allograft dysfunction.

Dr. Keller serves as Local Site Director of the Mid-Atlantic Mechanical Ventilation Course, Educational Consortium. He is on the faculty for preceptorial courses for Critical Care fellows at NIH, and Pulmonary and Critical Care fellows at NIH, Washington Hospital Center, and the University of Pittsburgh.

Dr. Keller values the concept of the bench-to-bedside approach inherent to translational research, applying novel cutting edge technologies to the clinical realm to advance the field of lung transplantation and critical care. He also values his role as an educator and has a strong passion for teaching the next generation of physicians to become strong clinicians and physician-scientists.

• National Heart, Lung, and Blood Institute Orloff Science Award, 2022
• NIH Clinical Center CEO Award, ICU/IMC COVID Response Team, 2020

Keller M, Wang J, Nason M, Warner S, Follmann D, Kadri S. Pre-intubation SOFA Score for Predicting COVID-19 Mortality: External Validation using EHR from 86 U.S. Healthcare Systems to Appraise Current Ventilator Triage Algorithms. Critical Care Medicine, In press

Keller M, Bush E, Diamond JM, Shah P, Matthew J, Brown AW, Sun J, Timofte I, Kong H, Tunc I, Luikart H, Iacono A, Nathan SD, Khush KK, Orens J, Jang M, Agbor-Enoh S. Use of donor-derived-cell-free DNA as a marker of early allograft injury in primary graft dysfunction (PGD) to predict the risk of chronic lung allograft dysfunction (CLAD). The Journal of Heart and Lung Transplantation. 2021 Jun;40(6):488-493. doi: 10.1016/j.healun.2021.02.008.

Keller M, Sun J, Mutebi C, Shah P, Levine D, Aryal S, Iacono A, Timofte I, Mathew J, Varghese A, Giner C, Agbor-Enoh S. Donor-derived cell-free DNA as a composite marker of acute lung allograft dysfunction in clinical care. J Heart Lung Transplant. 2021 Dec 26:S1053-2498(21)02630-9. doi: 10.1016/j.healun.2021.12.009.

Keller M, Mutebi C, Shah P, Levine D, Aryal S, Iacono A, Timofte I, Mathew J, Varghese A, Giner C, Agbor-Enoh S. Biological Variation of Donor-Derived Cell-Free DNA in Stable Lung Transplant Recipients. J Appl Lab Med. 2022 Jan 12:jfab171. doi: 10.1093/jalm/jfab171.

Keller M, Agbor-Enoh S. Donor-Derived Cell-Free DNA for Acute Rejection Monitoring in Heart and Lung Transplantation. Current Transplantation Reports 8, 351–358 (2021).

Jang MK, Tunc I, Berry GJ, Marboe C, Kong H, Keller MB, Shah PD, Timofte I, Brown AW, Ponor IL, Mutebi C, Philogene MC, Yu K, Iacono A, Orens JB, Nathan SD, Agbor-Enoh S. Donor-derived cell-free DNA accurately detects acute rejection in lung transplant patients, a multicenter cohort study. J Heart Lung Transplant. 2021 Aug;40(8):822-830. doi: 10.1016/j.healun.2021.04.009.

Agbor-Enoh S, Oellerich M, Wu A, Halloran PF, De Vlaminck I, Keller M. Molecular Approaches to Transplant Monitoring; Is the Horizon Here? Clin Chem. 2021 Nov 1;67(11):1443-1449. doi: 10.1093/clinchem/hvab183.

Kadri SS, Sun J, Lawandi A, Strich JR, Busch LM, Keller M, Babiker A, Yek C, Malik S, Krack J, Dekker JP, Spaulding AB, Ricotta E, Powers JH 3rd, Rhee C, Klompas M, Athale J, Boehmer TK, Gundlapalli AV, Bentley W, Datta SD, Danner RL, Demirkale CY, Warner S. Association Between Caseload Surge and COVID-19 Survival in 558 U.S. Hospitals, March to August 2020. Ann Intern Med. 2021 Sep;174(9):1240-1251. doi: 10.1016/j.healun.2021.02.008.

Visit PubMed.gov for a full list of Dr. Keller's publications.