Andrew Mannes, MD, ME, MBA

BS, University of Pennsylvania
ME, Dartmouth College
MBA, University of Maryland, University College
MD, George Washington University

Dr. Mannes is chief of the Clinical Center's Department of Perioperative Medicine. His current interests include developing pain therapies using gene therapy; targeting pain pathways with selective agonists, toxins, or fusion proteins; and improving the diagnosis of disease states using proteomic and genomic techniques.

He has written widely in books and medical journals on such topics as advances in cancer pain management, gene therapy for pain, and neurosurgical intervention approaches to pain relief. He is board certified in anesthesiology and fellowship-trained in pain management.

He collaborates with the Clinical Center's Pain and Palliative Care Service in the area of pain management and has also worked on treatment of chronic pain with investigators from several NIH intramural programs. He manages the Department of Perioperative Medicine laboratory which is focused on gaining insight into nociceptive and other sensory pathways to identify new approaches for treating pain.

Following completion of a Bachelor of Science degree in Bio-Engineering at the University of Pennsylvania and a Master of Engineering degree at Dartmouth College, Dr. Mannes received his MD degree at George Washington University. He completed a transitional internship at the Presbyterian Hospital of Philadelphia followed by an anesthesia residency at the Hospital of the University of Pennsylvania. While at University of Pennsylvania, he completed a fellowship in pain management and joined the Penn faculty as an Instructor in Anesthesiology in 1994. In 2019, he received his MBA degree from the University of Maryland, University College.

He was promoted to Assistant Professor of Anesthesiology in 1997 before coming to NIH. Dr. Mannes completed an NIH research fellowship in molecular biology in 1997. He has been in the Department of Anesthesia and Surgical Services since 2001.

Dr. Mannes is a member of the American Medical Association and is on the editorial advisory board of Open Pain Journal.

See his Intramural Research Program bio page.

• Clinical Center Nursing Award (Team Excellence Award), 2018
• National Institutes of Health Clinical Center Director's Award, 2016
• NIH Director's Award for work on advancing resiniferatoxin to a successful IND approval, enabling its evaluation in clinical trials as a treatment for intractable pain, 2009
• Hexagon Society (University of Pennsylvania), 1981

Book Chapters

Kim PS, Staats PS, Deer TR, Iadarola MJ, Mannes AJ. Intrathecal Drug Delivery for Cancer Pain. Elsevier (in Press 2019).

Tobias M, Mannes AJ: Management of Postoperative and Other Acute Pain. In: The Intensive Care Unit Manual. Second edition. 2014 Elsevier, Philadelphia, PA.

Mannes AJ, Kim PS, Lonser R. Neurosurgical Interventional Approaches to Pain in the 4th edition of Principles and Practice of Palliative Care and Supportive Oncology. 2012.

Mannes AJ, Kim PS, Lonser R. Neurosurgical Interventional Approaches to Pain in the 3rd edition of Principles and Practice of Palliative Care and Supportive Care. 2005.

Mannes AJ, Tobias MD, Lonser R. Neurosurgical and Interventional Approaches in Cancer Pain Management. In: Advances in Cancer Pain. Oncology Group, CMP Communications. 2004.

Yeoman D, Mannes AJ, Saitoh Y. Gene therapy for pain: Different approaches toward a common goal. In: Proceeding of the World Congress on Pain. 2003. IASP Press Seattle, WA.

Iadarola MJ, Lee S, Mannes AJ: Gene transfer approaches to pain control. In: Molecular Neurobiology of Pain. D. Borsook (Ed.) Progress in Pain Research and Management 9:337-359, 1997. IASP Press Seattle, WA.

Journal Articles

Pritchard WF, Karanian JW, Jung C, Bakhutashvili I, Reed SL, Froelke BR, Barnes T, Stevenson D, Strasser W, Mendosa A, Eckstein D, Wood BJ, Walsh BK, Mannes AJ. Miniature 3D printed pressure-cycled ventilator maintains respiratory homeostasis in swine with induced acute pulmonary injury. (Science Translational Medicine, 2022).

Miao N, Lu X, Orfgen S, Mannes AJ. Intercostal nerve cryoablation: An alternate method for pain management during thoracotomy-A case report. (Translational Periop and Pain Med 2022).

Iadarola MJ, Mannes AJ. Be in it for the long haul: a commentary on human tissue recovery initiatives. (J Pain, 2022).

Kim JJ, Sapio MR, Vazquez FA, Dragan M, Loydpierson A, Zarate C, Iadarola MJ, Mannes AJ. Ketamine. Transcriptional activation, deactivation and rebound patterns in cortex, hippocampus and amygdala in response to ketamine infusion (Frontiers in Molecular Neuroscience, 2022)

Iadarola MJ, Nahama A, Brown DC, Mannes AJ. Pain treatment in canine companion model Î to validate early-stage results and incentivize transition to Human Clinical Trials. (Frontiers in Pharmacology, 2021)

Sapio MR, Kim JJ, Loydpierson A, Dragan M, Goto T, Vazquez FA, Muhly WT, Iadarola MJ, Mannes AJ. The persistent pain transcriptome: identification of cells and molecules activated by hyperalgesia. (J Pain 2021)

Sapio MR, Iadarola MJ, Loydpierson AJ, Maric D, Kim JJ, Mannes AJ. Dynorphin and Enkephalin Opioid peptides and transcripts in spinal cord and dorsal root ganglia during peripheral inflammatory hyperalgesia and allodynia. (2020, J Pain).

Iadarola MJ, Brown DC, Sapio MR, Mannes AJ. On the Threshold of a New Analgesic: Shaping a Novel Treatment for Osteoarthritis Pain. (Pain Research Forum, 2018).

Raithel SJ, Sapio MR, LaPaglia DM, Iadarola MJ, Mannes AJ. Transcriptional changes in dorsal spinal cord persist after surgical incision despite preemptive analgesia with peripheral resiniferatoxin. Anesthesiology 2018.

Raithel SJ, Sapio MR, Iadarola MJ, Mannes AJ. Thermal A-δ nociceptors, identified by transcriptomics, express higher levels of anesthesia-sensitive receptors than thermal C-fibers and are more suppressible by low-dose isoflurane. Anesthesia & Analgesia. 2018.

LaPaglia DM, Sapio MR, Burbelo PD, Thierry-Mieg J, Thierry-Mieg D, Ramsden CE, Iadarola MJ, Mannes AJ. RNA-SEQ investigations of human postmortem trigeminal ganglia related to headache and migraine. (Cephalalgia 2018)

Aron J, Raitel S, Mannes AJ. Torus Palatinus and Airway Management. (Anesthesiology 2017).

Mannes AJ, Iadarola MJ. Complete pain relief: potential problems and diagnostic solutions. Nature Clin Pract Neurol. 3 (12): 648-649 2007.

Mannes AJ, Iadarola MJ. Potential downsides of perfect pain relief. Nature vol. 446 pg 24 2007.

Brown, DC, Iadarola MJ, Perkowski SZ, Hardam ED, Shofer F, Karai L, Olah, Z, Mannes, AJ. Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model. Anesthesiology. 103(5) 1052-1059. 2005.

Visit PubMed.gov for a full list of Dr. Mannes's publications.